From Santa Lucia train station of from Piazzale Roma: waterbus line 1 or 2 get off at Rialto Bridge stop.
From Venice Airport: bus number 5 till Piazzale Roma (bus terminal), then waterbus line 1 or 2.
From the airport is available also a water service ALILAGUNA till Rialto or San Mark.
From Rialto stop, take right and pass the first bridge, take left in calle Bembo for 100m, you will find the hotel on the left. From San Mark Square take Calle dei Fabbri behind the famous Quadri cafè and follow for 300m.